Nitric oxide synthase in spontaneously hypertensive rats

摘要: Since its discovery by Furchgott and Zawadzki in 1980 [18], endothelium-derived relaxing factor (EDRF) has been shown to play a central role the cardiovascular system [10]. The endothelial product is chemically equivalent nitric oxide (NO) [23, 40] or biochemical congener thereof [48]. Fifteen years ago, this small, simple highly toxic molecule was known as lengthy list of environmental pollutants found unsavory haunts such smoke smog, even destroyer ozone, suspected carcinogen, precursor acid rain. In addition, NO seems an unlikely biological jack all trades for most body's functions are regulated extraordinarily large complex proteins compounds. But over past decade, diverse lines evidence have converged show that sometime poison fundamental player everyday business human body.