A prime/boost strategy using DNA/fowlpox recombinants expressing the genetically attenuated E6 protein as a putative vaccine against HPV-16-associated cancers
作者： Massimiliano Bissa , Elena Illiano , Sole Pacchioni , Francesca Paolini , Carlo Zanotto
DOI: 10.1186/S12967-015-0437-9
关键词: Vaccination 、 Fowlpox 、 Genotype 、 Cervical cancer 、 Cancer cell 、 Papilloma 、 Viral replication 、 Biology 、 Fowlpox virus 、 Virology
摘要: Background Considering the high number of new cases cervical cancer each year that are caused by human papilloma viruses (HPVs), development an effective vaccine for prevention and therapy HPV-associated cancers, in particular against high-risk HPV-16 genotype, remains a priority. Vaccines expressing E6 E7 proteins detectable all HPV-positive pre-cancerous cells might support treatment HPV-related lesions clear already established tumors.
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