Cancer Epigenetics: Dna Methylation and Chromatin Alterations in Human Cancer
作者： Manel Esteller
DOI: 10.1007/978-1-4615-0081-0_5
关键词: Cancer research 、 DNA methylation 、 Epigenetics 、 Biology 、 Epigenomics 、 Tumor suppressor gene 、 Chromatin remodeling 、 CpG site 、 DNA repair 、 Cancer epigenetics
摘要: Aberrations in the DNA methylation patterns are nowadays recognized as a hallmark of human cancer One most characteristic changes is hypermethylation CpG islands tumor suppressor genes associated with their transcriptional silencing The target distributed all cellular pathways (apoptosis, repair, cell cycle, adherence, etc) They “classical” familial cancers (BRCA1, hMLH1, p16lNK4aVHL, and putative new which loss may contribute to transformed phenotype (MGMT, p14ARF, GSTP1, RARB2, A tumor-type specific profile island exist that allows use these aberrantly hypermethylated loci biomarkers malignant disease irruption technologies for careful study patterns, genetic partners accomplishing gene silencing, it also provide us drugs epigenetic treatment tumors
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