Perfluoro tertiary alcohols. III. (Perfluoroalkyl)- and (perfluorooxaalkyl)-trimethylsilanes in the synthesis of perfluorinated tertiary alcohols☆
作者： Grace J. Chen , Loomis S. Chen , Kalathil C. Eapen , Wayne E. Ward
DOI: 10.1016/0022-1139(94)03068-5
关键词: Yield (chemistry) 、 Tertiary alcohols 、 Medicinal chemistry 、 Alcohol 、 Ketone 、 Trifluoromethyl 、 Organic chemistry 、 Chemistry
摘要: Abstract High-molecular weight perfluorinated tertiary alcohols, R f 1 2 3 C(OH) = n-C 8 F 17 , =CF =n-C 6 13 ; (CF ) CFO(CF 4 CF ,·R C 7 O[CF(CF )CF O] CF(CF ), O[CF )O] ( IIIa–d have been prepared by the reactions of (perfluoroalkyl)- and (perfluorooxaalkyl)-trimethylsilanes Ia–d with fluoroketones IIa–c ). Ketones containing a trifluoromethyl group as well higher molecular substituents studied under different experimental conditions. The yield alcohol is influenced solvents, reaction temperatures, type concentration metal fluorides, structures fluoroalkyltrimethylsilanes fluoroketones. has extended to carbonyl compounds other than ketones. While secondary acid fluoride gave good ketone, no was observed esters.
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