Diastereoselective synthesis of enantiopure differentially protected cis-4,5-diaminopiperidin-2-one through intramolecular transamidation
作者： Nicole Langlois
DOI: 10.1016/S0040-4039(02)02418-8
关键词: Intramolecular force 、 Chemistry 、 Combinatorial chemistry 、 Enantiopure drug 、 Conjugate 、 Ring (chemistry) 、 Stereochemistry 、 Organic chemistry 、 Biochemistry 、 Drug discovery
摘要: The diastereoselective synthesis of enantiopure differentially protected cis-4,5-diaminopiperidin-2-one was achieved by means conjugate addition ammonia to an unsaturated γ-lactam and transamidation reaction with ring expansion as the main steps.
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