Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants

摘要: In the last few years, there have been several advances in determination of role endocannabinoid system etiology depression and functional actions antidepressant drugs. Specifically, a deficiency signaling is sufficient to produce "depressive-like" phenotype at preclinical level (including changes rewarding, emotional cognitive behavior biological such as increased HPA axis activity, impaired stress adaptation, reduced neurogenesis altered serotonin negative feedback), capable inducing symptoms humans clinical level. line with these findings, populations diagnosed are found levels circulating endocannabinoids models reveal deficit central signaling. Moreover, facilitation all behavioral biochemical effects conventional treatments. Further, many forms treatments significantly alter signaling, some cases this recruitment involved neuroadaptive Ultimately, data present compelling picture putative processes subserving both development treatment depression.