The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects.

摘要: Aim: To analyze age-related cerebral blood flow (CBF) using arterial spin labeling (ASL) MRI in healthy subjects with multivariate principal component analysis (PCA). Methods: 50 (mean age 45.8 ± 18.5 years, range 21-85) had 3D structural and pseudo-continuous ASL at resting state. The relationship between CBF was examined voxel-based univariate multiple regression two-sample t-test (median 41.8 years as a cut-off). An pattern identified PCA. Results: Age correlated negatively especially anteriorly cerebellum. After adjusting by global value, relatively decreased aging certain regions increased others. showed relative reductions frontal parietal areas cerebellum, covarying increases temporal occipital areas. Subject scores of this (R2 = 0.588; P < 0.001) discriminated the older younger subgroups (P 0.001). Conclusion: A distinct can be PCA MRI.