Effects of Cocaine on Luteinizing Hormone in Women during the Follicular and Luteal Phases of the Menstrual Cycle and in Men

摘要: Cocaine stimulates luteinizing hormone (LH) release in rhesus monkeys and men, but its effects on LH women are unknown. (0.2 0.4 mg/kg i.v.) was administered to groups of follicular luteal phase ( N = 22) men 12) examine the influence gender menstrual cycle cocaine interactions. All subjects met American Psychiatric Association Diagnostic Statistical Manual IV criteria for abuse, verified by estradiol progesterone measures. Baseline levels were equivalent between groups. Peak did not differ significantly averaged 87 ± 21 124 18 ng/ml after 0.2 227 22 287 cocaine. The lower dose mg/kg) increased P < 0.001) at either cycle. higher (0.4 stimulated significant increases both phases 0.004–0.001). Although cocaine's dose-dependent, there no differences as a function phase. remained elevated longer (32 min) than (8 12 min). This difference potency stimulating unexpected.