Aromatic-dependent Salmonella as anti-bacterial vaccines and as presenters of heterologous antigens or of DNA encoding them

作者: B.A.D Stocker

DOI: 10.1016/S0168-1656(00)00297-2

关键词: Ty21aBacterial vaccineSalmonellaAntigenEnterobacteriaceaeVirologyMicrobiologySalmonella typhiAroaBiologyTyphoid fever

摘要: The development of live bacterial vaccines is reviewed, in particular aromatic-dependent Salmonella, either for protection against the corresponding infections (including typhoid fever) or as carrier-presenter antigens unrelated pathogens DNA specifying them. Aromatic-dependent Salmonella are also compared with BCG and Ty21a recent records exceptional situations discussed which aroA (deletion) strains typhimurium cause progressive disease mice.

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