Contributions of body mass index and exercise habits on inflammatory markers: a cohort study of middle-aged adults living in the USA

摘要: Objectives Determine whether body mass index (BMI) and physical activity (PA) above, at or below MET minute per week (MMW) levels recommended in the 2008 Physical Activity Guidelines interact have additive effects on interleukin (IL)-6, C reactive protein (CRP), fibrinogen, interleukin6 (IL-6) soluble receptor (IL-6sr), E-selectin intracellular adhesion molecule (sICAM)-1. Design Archived cohort data (n=1254, age 54.5±11.7 year, BMI 29.8±6.6 kg/m2) from National Survey of Midlife Development USA (MIDUS) Biomarkers Study were analysed for concentrations inflammatory markers using general linear models. MMW was defined as no regular exercise, 1000 MMW Setting Respondents reported to three centres complete questionnaires provide blood samples. Participants men women currently enroled MIDUS Biomarker Project 93% non-Hispanic white, average 54.5 years). Primary outcome measures Concentration serum IL-6, CRP, IL-6sr, sE-selectin sICAM. Results Significant interactions found between CRP sICAM-1 (p compared obese individuals reporting less exercise. Conclusions The association exercise with differed by BMI, suggesting that may buffer weight-associated elevations overweight while higher be necessary reduce individuals.