Does physical activity increase or decrease the risk of sickle cell disease complications

摘要: Sickle cell disease (SCD) is the most common inherited in world. Red blood sickling, cell-endothelium adhesion, rheology abnormalities, intravascular haemolysis, and increased oxidative stress inflammation contribute to pathophysiology of SCD. Because acute intense exercise may alter these pathophysiological mechanisms, physical activity usually contra-indicated patients with However, recent studies sickle-cell trait carriers a SCD mice model show that regular could decrease inflammation, limit alterations increase nitric oxide metabolism. Therefore, supervised habitual benefit This article reviews literature on effects chronic biological responses clinical outcomes