Do we have to consider acidosis induced by exercise as deleterious in sickle cell disease

摘要: New findings What is the topic of this review? The aim review to discuss potential involvement exercise-induced acidosis in commonly reported complications sickle cell disease. advances does it highlight? Blood appears clearly be a risk factor for HbS polymerization, red blood sickling and occurrence vaso-occlusive crisis could induce hyperkalaemia-related complications. It great interest try avoid during exercise, which done using some alkalinizing solutions or adapted endurance training interventions. Abstract Sickle disease (SCD) an inherited haemoglobin (Hb) disorder most common monogenic world. root cause pathology synthesis abnormal Hb (HbS) that polymerizes deoxygenated conditions, leading cells. Acidosis well recognized as promoter polymerization therefore sickling. Indeed, has been shown vitro relative amount sickled cells increases markedly from 1% at pH 7.4 >90% 7.0. Nevertheless, no study directly tested whether favour SCD Greater knowledge effects metabolic exercise importance given conclusions reached several studies proposed regular physical therapeutic strategy management SCD. In review, we consequences pathophysiology We also propose interventions with reducing related exercise.