Acid-Base Homeostasis in the Brain: Physiology, Chemistry, and Neurochemical Pathology

作者: Bo K. Siesjö

DOI: 10.1016/S0079-6123(08)61980-9

关键词:

摘要: Publisher Summary This chapter discusses the current information on brain acid-base metabolism in health and disease. The deals with some of conceptual difficulties applying theory to systems having composition extra- intracellular fluids. features cellular regulation extracerebral tissues are discussed, corresponding pH is described. changes e i disease discussed. considers possible molecular mechanisms, whereby acidosis can cause or aggravate cell injury. describes behavior simulated fluid, two additional equations, describing ionization a weak acid (Ha), conservation mass—that is, constancy total buffer concentration (C),

参考文章(125)
Philip Aisen, Some physicochemical aspects of iron metabolism. Ciba Foundation symposium. pp. 1- 17 ,(1976) , 10.1002/9780470720325.CH1
William M. Wallace, A. Baird Hastings, THE DISTRIBUTION OF THE BICARBONATE ION IN MAMMALIAN MUSCLE Journal of Biological Chemistry. ,vol. 144, pp. 637- 649 ,(1942) , 10.1016/S0021-9258(18)72487-3
Kyuya Kogure, Hiroyuki Arai, Koji Abe, Minoru Nakano, Free Radical Damage of the Brain Following Ischemia Molecular Mechanisms of Ischemic Brain Damage. ,vol. 63, pp. 237- 259 ,(1985) , 10.1016/S0079-6123(08)61987-1
Gabriel G. Nahas, Current concepts of acid-base measurement New York Academy of Sciences. ,(1966)
Richard P. Kraig, William A. Pulsinelli, Fred Plum, Heterogeneous Distribution of Hydrogen and Bicarbonate Ions During Complete Brain Cischemia Molecular Mechanisms of Ischemic Brain Damage. ,vol. 63, pp. 155- 166 ,(1985) , 10.1016/S0079-6123(08)61981-0
H. K. Kimelberg, R. S. Bourke, Anion Transport in the Nervous System Springer, Boston, MA. pp. 31- 67 ,(1982) , 10.1007/978-1-4757-0614-7_2
J D Crapo, B A Freeman, Biology of disease: free radicals and tissue injury. Laboratory Investigation. ,vol. 47, pp. 412- 426 ,(1982)
K. G. M. M. Alberti, C. Cuthbert, The hydrogen ion in normal metabolism: a review. Ciba Foundation symposium. ,vol. 87, pp. 1- 19 ,(1982) , 10.1002/9780470720691.CH1
P Vigne, C Frelin, M Lazdunski, The amiloride-sensitive Na+/H+ exchange system in skeletal muscle cells in culture. Journal of Biological Chemistry. ,vol. 257, pp. 9394- 9400 ,(1982) , 10.1016/S0021-9258(18)34083-3
Theodore Cedric Ruch, Harry D. Patton, Physiology and biophysics Saunders , Igaku Shoin. ,(1965)