Molecular Mechanisms of Acidosis-Mediated Damage
作者： Bo. K. Siesjö , K. I. Katsura , T. Kristián , P.-A. Li , P. Siesjö
DOI: 10.1007/978-3-7091-9465-2_2
关键词:
摘要: The present article is concerned with mechanisms which are responsible for the exaggerated brain damage observed in hyperglycemic animals subjected to transient global or forebrain ischemia. Since hyperglycemia enchances production of lactate− plus H+ during ischemia, it seems likely that aggravation due intra- and extracellular acidosis. This contention supported by results showing a detrimental effect extreme hypercapnia normoglycemic rats ischemia hypoglycemic coma.
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