Synthesis of Substituted 3-Pyridinecarbonitriles with Potential Biological Activity
作者： C. Oliver Kappe , Thomas Kappe
DOI: 10.1007/BF00809291
关键词: Combinatorial chemistry 、 Phosphorus 、 Organic chemistry 、 Condensation 、 Nucleophile 、 Biological activity 、 Chemistry
摘要: The synthesis of some 5-cyano-4-hydroxy-2-pyridone derivatives (3 a–c) by condensation 3-aminocrotononitrile (1) with substituted diethylmalonates (2 is described. Reaction of3 a phosphorus oxychloride yields 4,6-dichloro-3-pyridinecarbonitrile (7 a), which reacts various nucleophiles to give 3-pyridinecarbonitriles (8–10).
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