Nuclear Accumulation of p53 Is a Potential Marker for the Development of Squamous Cell Lung Cancer in Smokers

摘要: Study objectives To determine whether the nuclear accumulation of p53 in patients with early bronchial neoplasia represents an altered susceptibility for development lung cancer. Patients and measurements We evaluated percentage cells accumulating immunohistochemically squamous cell carcinoma (SCC) lung, associated uninvolved mucosa, epithelial hyperplasia 60 archival specimens smokers normal epithelium hyperplastic lesions who had not developed Results The was significantly higher SCC-associated epithelia (mean [± SD], 4 ± 0.9%) from (mean, 9 2%) compared to 0.5 0.2%) 1.5 0.5%) were cancer (p = 0.0002 p 0.0004, respectively). also observed a statistically significant stepwise increase those patient SCC 35 4%), suggesting involvement ≤ 0.05 all comparisons). size tumor, nodal involvement, stage disease, presence or absence metastasis, grade differentiation, survival indicating its lack association clinical progression disease. Conclusions These results suggested that is event carcinogenesis potentially could be useful identification are at risk developing SCC, but estimation