Epidermal growth factor receptor mutation and p53 overexpression during the multistage progression of small adenocarcinoma of the lung.
作者： Seol Bong Yoo , Jin-Haeng Chung , Hyun Ju Lee , Choon-Taek Lee , Sanghoon Jheon
DOI: 10.1097/JTO.0B013E3181DD15C0
关键词: Molecular biology 、 Adenocarcinoma of the lung 、 Biology 、 Atypical adenomatous hyperplasia 、 Adenocarcinoma 、 Cancer research 、 Point mutation 、 Epidermal growth factor receptor 、 EGFR Gene Mutation 、 Carcinogenesis 、 Exon
摘要: Introduction A progression model of atypical adenomatous hyperplasia (AAH) to bronchioloalveolar carcinoma (BAC) invasive adenocarcinoma (ADC) has been proposed. However, the genetic alterations AAH-BAC-ADC sequence are not clearly established. We examined mutation epidermal growth factor receptor ( EGFR ) gene and p53 protein overexpression in AAH, BAC, small ADC understand their role pulmonary pathogenesis. Methods Twenty 43 BAC (21 Noguchi type 22 B), 47 (Noguchi C) were enrolled this study. mutations at exons 18–21 by polymerase chain reaction-direct sequencing immunohistochemistry, respectively. Results Mutations noted 45 (40.9%) lesions, which included 7 (35.0%) 15 (34.9%) 23 (48.9%) ADC. Twenty-six (23.6%) detected as exon 19 deletion, 18 (16.4%) 21 point mutation, 1 (0.9%) mutation. Overexpression was found (17.2%) none 4 (9.8%) (31.9%) Multivariate analysis showed that associated with P = 0.003). Conclusions High frequency similar incidence support occurs early stage development tumor initiation from preneoplastic lung parenchyma neoplastic conditions. On contrary, is a late event during plays peripheral
jto.org
sci-hub.se 参考文章(33)
M J Baek, H Kang, S E Kim, J H Park, J S Lee, Y-K Paik, H Kim, Expression of hMLH1 is inactivated in the gastric adenomas with enhanced microsatellite instability British Journal of Cancer. ,vol. 85, pp. 1147- 1152 ,(2001) , 10.1054/BJOC.2001.2051
Takashi Nishisaka, Kouki Inai, Souichi Kitaguchi, Yukio Takeshima, Proliferative Activity, p53 Expression and Loss of Heterozygosity on 3p, 9p and 17p in Atypical Adenomatous Hyperplasia of the Lung Hiroshima journal of medical sciences. ,vol. 47, pp. 17- 25 ,(1998)
Ximing Tang, Hisayuki Shigematsu, B. Nebiyou Bekele, Jack A. Roth, John D. Minna, Waun Ki Hong, Adi F. Gazdar, Ignacio I. Wistuba, EGFR Tyrosine Kinase Domain Mutations Are Detected in Histologically Normal Respiratory Epithelium in Lung Cancer Patients Cancer Research. ,vol. 65, pp. 7568- 7572 ,(2005) , 10.1158/0008-5472.CAN-05-1705
Adi F. Gazdar, Shinichi Toyooka, Kazunori Tsukuda, Mitsune Tanimoto, Masahiro Tabata, Kouichi Ichimura, Masaaki Yano, Toshihide Tsuda, Hisayuki Shigematsu, Hiroshi Date, Kunitoshi Tomii, Nobuyoshi Shimizu, Hiroshi Ueoka, Motoi Aoe, Masaki Tokumo, Katsuyuki Kiura, The Relationship between Epidermal Growth Factor Receptor Mutations and Clinicopathologic Features in Non–Small Cell Lung Cancers Clinical Cancer Research. ,vol. 11, pp. 1167- 1173 ,(2005)
Wade S. Samowitz, Joseph A. Holden, Karen Curtin, Sandra L. Edwards, Adrianne R. Walker, Heather A. Lin, Margaret A. Robertson, Melanie F. Nichols, Kristin M. Gruenthal, Beverly J. Lynch, Mark F. Leppert, Martha L. Slattery, Inverse Relationship between Microsatellite Instability and K-ras and p53 Gene Alterations in Colon Cancer American Journal of Pathology. ,vol. 158, pp. 1517- 1524 ,(2001) , 10.1016/S0002-9440(10)64102-8
Sylvie Lantuéjoul, Dimitri Salameire, Caroline Salon, Elisabeth Brambilla, Pulmonary preneoplasia--sequential molecular carcinogenetic events. Histopathology. ,vol. 54, pp. 43- 54 ,(2009) , 10.1111/J.1365-2559.2008.03182.X
Curtis C. Harris, COMMENTARY: p53 Tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective Carcinogenesis. ,vol. 17, pp. 1187- 1198 ,(1996) , 10.1093/CARCIN/17.6.1187
Masayuki Noguchi, Akio Morikawa, Masanori Kawasaki, Yoshihiro Matsuno, Tesshi Yamada, Setsuo Hirohashi, Haruhiko Kondo, Yukio Shimosato, Small adenocarcinoma of the lung. Histologic characteristics and prognosis Cancer. ,vol. 75, pp. 2844- 2852 ,(1995) , 10.1002/1097-0142(19950615)75:12<2844::AID-CNCR2820751209>3.0.CO;2-#
H Sakamoto, J Shimizu, Y Horio, R Ueda, T Takahashi, T Mitsudomi, Y Yatabe, Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas. The Journal of Pathology. ,vol. 212, pp. 287- 294 ,(2007) , 10.1002/PATH.2165
Chandrika J Piyathilake, Andra R Frost, Upender Manne, Heidi Weiss, Douglas C Heimburger, William E Grizzle, None, Nuclear Accumulation of p53 Is a Potential Marker for the Development of Squamous Cell Lung Cancer in Smokers Chest. ,vol. 123, pp. 181- 186 ,(2003) , 10.1378/CHEST.123.1.181