Effect of Positive Well-Being on Incidence of Symptomatic Coronary Artery Disease

摘要: Although negative emotions and psychiatric morbidity have often been found to increase incident coronary artery disease (CAD) risk, fewer studies shown positive be protective against CAD; none performed in high-risk healthy populations, taking risk factors into account. Thus, we examined the effect of well-being on CAD both a initially population national probability sample. We screened siblings probands with documented early-onset from 1985 2007 GeneSTAR (Genetic Study Atherosclerosis Risk) sociodemographic data, factors, using General Well-Being Schedule. further classified high-, intermediate-, low-risk strata according Framingham score followed them for 5 25 years. Siblings (n = 1,483) greater baseline Schedule total scores were significantly less likely develop (hazard ratio 0.67, 95% confidence interval 0.58 0.79), independent age, gender, race, traditional factors. Protection was strongest high stratum 0.52, 0.30 0.90). The findings replicated first National Health Nutrition Examination Survey Epidemiologic Follow-up 5,992; hazard 0.87, 0.83 0.93). In conclusion, associated nearly 1/3 reduction family history, 50% highest those 13% sample,