Hydrogel-nanoparticles composite system for controlled drug delivery
作者： Emanuele Mauri , Anna Negri , Erica Rebellato , Maurizio Masi , Giuseppe Perale
DOI: 10.3390/GELS4030074
关键词: Dynamic light scattering 、 Composite number 、 Electric charge 、 Diffusion 、 Drug delivery 、 Chemical engineering 、 Nanoparticle 、 Materials science 、 Self-healing hydrogels 、 Ethylene glycol
摘要: Biodegradable poly(ethylene glycol)-block-poly(-lactic acid) (PEG-b-PLA) nanoparticles (NPs) were prepared by nanoprecipitation with controlled dimension and different electric charges, as monitored dynamic light scattering (DLS). Then NPs loaded within hydrogels (HG) developed for biomedical applications in the central nervous system, pore sizes (30 90 nm). The characteristics of resulting composite hydrogel-NPs system firstly studied terms ability to control release small steric hindrance drug mimetic. Then, diffusion-controlled charged from entangled was vitro correlated charges hydrogel mean mesh size. These studies showed trends, that depend on superficial charge HG Release experiments diffusion studies, then rationalized mathematical modeling, allowed us build delivery devices can satisfy medical needs.
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