Differences in TGF-β1 signaling and clinicopathologic characteristics of histologic subtypes of gastric cancer

作者: Kyung Ho Pak , Dong Hoon Kim , Hyunki Kim , Do Hyung Lee , Jae-Ho Cheong

DOI: 10.1186/S12885-016-2091-X

关键词: Clinicopathological featuresPathologyCell signalingTgf β1 signalingMedicineSignal transductionRegulation of gene expressionCarcinogenesisCancerSurgical oncology

摘要: Background Aberrant TGF-β1 signaling is suggested to be involved in gastric carcinogenesis. However, the role of intestinal-type [i-GC] and diffuse-type [d-GC] cancer remains largely unknown. In this study, we evaluated expression molecules compared clinicopathological features i-GC d-GC.

参考文章(19)
Cheol Keun Park, Young Kee Shin, Yoon-La Choi, Seok-Hyung Kim, Li-Hui Wang, Seung-Hyun Lee, Extensive alteration in the expression profiles of TGFB pathway signaling components and TP53 is observed along the gastric dysplasia-carcinoma sequence. Histology and Histopathology. ,vol. 23, pp. 1439- 1452 ,(2008) , 10.14670/HH-23.1439
Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray, Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer. ,vol. 136, ,(2015) , 10.1002/IJC.29210
Bhagelu Ram Achyut, Li Yang, Transforming growth factor-β in the gastrointestinal and hepatic tumor microenvironment. Gastroenterology. ,vol. 141, pp. 1167- 1178 ,(2011) , 10.1053/J.GASTRO.2011.07.048
Y.H. Kim, H.S. Lee, H.-J. Lee, K. Hur, W.H. Kim, Y.-J. Bang, S.-J. Kim, K.U. Lee, K.J. Choe, H.-K. Yang, Prognostic significance of the expression of Smad4 and Smad7 in human gastric carcinomas Annals of Oncology. ,vol. 15, pp. 574- 580 ,(2004) , 10.1093/ANNONC/MDH131
Lukas JAC Hawinkels, Hein W Verspaget, Wim van Duijn, Johanna M van der Zon, Kim Zuidwijk, Frank JGM Kubben, Jan H Verheijen, Daniel W Hommes, Cormelis BHW Lamers, Cormelis FM Sier, None, Tissue level, activation and cellular localisation of TGF-β1 and association with survival in gastric cancer patients British Journal of Cancer. ,vol. 97, pp. 398- 404 ,(2007) , 10.1038/SJ.BJC.6603877
Hiroaki Ikushima, Kohei Miyazono, TGFβ signalling: a complex web in cancer progression Nature Reviews Cancer. ,vol. 10, pp. 415- 424 ,(2010) , 10.1038/NRC2853
Yasuhito Yuasa, Control of gut differentiation and intestinal-type gastric carcinogenesis. Nature Reviews Cancer. ,vol. 3, pp. 592- 600 ,(2003) , 10.1038/NRC1141
Naomi Uemura, Shiro Okamoto, Soichiro Yamamoto, Nobutoshi Matsumura, Shuji Yamaguchi, Michio Yamakido, Kiyomi Taniyama, Naomi Sasaki, Ronald J. Schlemper, Helicobacter pylori infection and the development of gastric cancer The New England Journal of Medicine. ,vol. 345, pp. 784- 789 ,(2001) , 10.1056/NEJMOA001999
Shoichi Kinugasa, Shun’ichi Abe, Mitsuo Tachibana, Yoshitaka Hishikawa, Hiroshi Yoshimura, Naomi Monden, Dipok Kumar Dhar, Naofumi Nagasue, Saburo Nagaoka, Overexpression of Transforming Growth Factor-β1 in Scirrhous Carcinoma of the Stomach Correlates with Decreased Survival Oncology. ,vol. 55, pp. 582- 587 ,(1998) , 10.1159/000011916