Extensive alteration in the expression profiles of TGFB pathway signaling components and TP53 is observed along the gastric dysplasia-carcinoma sequence.
作者： Cheol Keun Park , Young Kee Shin , Yoon-La Choi , Seok-Hyung Kim , Li-Hui Wang
DOI: 10.14670/HH-23.1439
关键词:
摘要: Aims: The expression patterns of TGFB signaling proteins, such as TGFB1/2, TGFBR1(ALK5), TGFBR2, SMAD1/2/3, SMAD2/3, SMAD4, SMAD7, and downstream targets signaling, CDKN1A (p21CIP1), CDKN1B (p27KIP1), MYC, CDC25A, TP53, RELA (p65NF-kB) were investigated in gastric carcinomas other lesions. Methods results: A total 112 carcinomas, 37 dysplasias, 54 intestinal metaplasias, 29 chronic atrophic gastritis normal epithelium analyzed by tissue microarray-based immunohistochemical analysis. Extensive changes profiles these proteins observed. Three types observed along the epithelium-atrophic gastritis-dysplasia-carcinoma sequence. (1) Expression TGFBR1, TP53 continually increased this (2) CDKN1A, was enhanced dysplasia but decreased carcinoma. (3) RELA, CDC25A level maintained In addition, we also evaluated clinical significance MYC positively correlated with advanced stages, whereas SMAD1/2/3 SMAD4 strongly associated earlier stages. Conclusions: extensive change components is implicated during tumorigenesis neoplasias.
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