Cancer-associated fibroblasts promote epithelial-mesenchymal transition and EGFR-TKI resistance of non-small cell lung cancers via HGF/IGF-1/ANXA2 signaling
作者： Yanmei Yi , Shanshan Zeng , Zhaotong Wang , Minhua Wu , Yuanhuan Ma
DOI: 10.1016/J.BBADIS.2017.12.021
关键词: Gene knockdown 、 Cancer research 、 Stromal cell 、 Tyrosine kinase 、 Epithelial–mesenchymal transition 、 Chemistry 、 Annexin A2 、 Gefitinib 、 Cell 、 Cancer-Associated Fibroblasts
摘要: … the Annexin A2 (ANXA2). More importantly, knockdown of ANXA2 completely reversed EMT … Furthermore, we found that CAFs increased the expression and phosphorylation of ANXA2 …
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