Mixed depression: clinical features and predictors of its onset associated with antidepressant use.

摘要: Background: Mixed depression (MxD) is narrowly defined in the DSM-IV and somewhat broader DSM-5, although both exclude psychomotor agitation as a diagnostic criterion. This article proposes clinical description for defining MxD, which emphasizes excitation. Methods: Two hundred nineteen consecutive outpatients were diagnosed with an MxD episode using criteria proposed by Koukopoulos et al. [Acta Psychiatr Scand 2007;115(suppl 433):50-57]; we here report their features antidepressant-related effects. Results: The most frequent symptoms were: psychic or inner tension (97%), absence of retardation (82%), dramatic suffering weeping spells (53%), talkativeness (49%), racing crowded thoughts (48%). was associated antidepressants 50.7% patients, similar frequency tricyclic (45%) versus selective serotonin reuptake inhibitors (38.5%). Positive predictors antidepressant-associated bipolar disorder type II diagnosis, higher index severity, age at episode. Antipsychotic no treatment protective against MxD. Conclusions: excitatory symptoms, can be clinically identified, common, occurs unipolar disorder, frequently antidepressant use. If replicated, this view could considered valid alternative to DSM-5 mixed features.