Stereotyped and specific gene expression programs in human innate immune responses to bacteria.

作者: J. C. Boldrick , A. A. Alizadeh , M. Diehn , S. Dudoit , C. L. Liu

DOI: 10.1073/PNAS.231625398

关键词: Innate immune systemMicrobiologyBacteriaLipopolysaccharideVirulenceAntigenGene expression profilingBiologyImmunityContext (language use)

摘要: The innate immune response is crucial for defense against microbial pathogens. To investigate the molecular choreography of this response, we carried out a systematic examination of …

参考文章(38)
Ruslan Medzhitov, Paula Preston-Hurlburt, Charles A. Janeway, A human homologue of the Drosophila Toll protein signals activation of adaptive immunity Nature. ,vol. 388, pp. 394- 397 ,(1997) , 10.1038/41131
Ena Wang, Lance D. Miller, Galen A. Ohnmacht, Edison T. Liu, Francesco M. Marincola, High-fidelity mRNA amplification for gene profiling. Nature Biotechnology. ,vol. 18, pp. 457- 459 ,(2000) , 10.1038/74546
Roberto Lorenzi, Paul M. Brickell, David R. Katz, Christine Kinnon, Adrian J. Thrasher, Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis Blood. ,vol. 95, pp. 2943- 2946 ,(2000) , 10.1182/BLOOD.V95.9.2943.009K17_2943_2946
Kerstin Wolk, Wolf-Dietrich Döcke, Volker von Baehr, Hans-Dieter Volk, Robert Sabat, Impaired antigen presentation by human monocytes during endotoxin tolerance Blood. ,vol. 96, pp. 218- 223 ,(2000) , 10.1182/BLOOD.V96.1.218
Z Zidek, Adenosine - cyclic AMP pathways and cytokine expression. European Cytokine Network. ,vol. 10, pp. 319- 328 ,(1999)
Beth D. Jamieson, Jerome A. Zack, Steve W. Cole, cAMP Up-Regulates Cell Surface Expression of Lymphocyte CXCR4: Implications for Chemotaxis and HIV-1 Infection Journal of Immunology. ,vol. 162, pp. 1392- 1400 ,(1999)
Lena Serrander, Petra Skarman, Birgitta Rasmussen, Walter Witke, Daniel P. Lew, Karl-Heinz Krause, Olle Stendahl, Oliver Nüße, Selective inhibition of IgG-mediated phagocytosis in gelsolin-deficient murine neutrophils. Journal of Immunology. ,vol. 165, pp. 2451- 2457 ,(2000) , 10.4049/JIMMUNOL.165.5.2451
David Relman, Elaine Tuomanen, Stanley Falkow, Douglas T. Golenbock, Kirsi Saukkonen, Samuel D. Wright, Recognition of a bacterial adhesin by an integrin: Macrophage CR3 (αMβ2, CD11bCD18) binds filamentous hemagglutinin of Bordetella pertussis Cell. ,vol. 61, pp. 1375- 1382 ,(1990) , 10.1016/0092-8674(90)90701-F
C. S. Detweiler, D. B. Cunanan, S. Falkow, Host microarray analysis reveals a role for the Salmonella response regulator phoP in human macrophage cell death Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 5850- 5855 ,(2001) , 10.1073/PNAS.091110098
Jeffrey S. Boschwitz, Janet West Batanghari, Hassya Kedem, David A. Relman, Bordetella pertussis Infection of Human Monocytes Inhibits Antigen-Dependent CD4 T Cell Proliferation The Journal of Infectious Diseases. ,vol. 176, pp. 678- 686 ,(1997) , 10.1086/514090