Simkania negevensis, an insight into the biology and clinical importance of a novel member of the Chlamydiales order.

摘要: Simkania negevensis is a Chlamydia-related bacterium discovered in 1993 and represents the founding member of Simkaniaceae family within Chlamydiales order. As other Chlamydiales, it an obligate intracellular characterized by biphasic developmental cycle. Its similarities with pathogenic Chlamydia trachomatis pneumoniae make interesting bacterium. So far, little known about its biology, but S. harbors various microbiological characteristics interest, including strong association Simkania-containing vacuole ER presence intron 23S rRNA encoding gene. Evidence human exposition has been reported worldwide. However, there lack robust clinical studies evaluating implication diseases; current data suggest pneumonia bronchiolitis making potential emerging pathogen. Owing to fastidious growth requirements, relevance probably underestimated. In this review, we summarize knowledge on explore future research challenges.