Obesity alters immune and metabolic profiles: New insight from obese-resistant mice on high-fat diet

摘要: Objective Diet-induced obesity has been shown to alter immune function in mice, but distinguishing the effects of from changes diet composition is complicated. It was hypothesized that immunological differences would exist between diet-induced obese (DIO) and obese-resistant (OB-Res) mice fed same high-fat (HFD). Methods BALB/c were either standard chow or HFD generate lean DIO OB-Res respectively. Resulting analyzed for serum immunologic metabolic profiles cellular parameters. Results BALB/c on categorized as OB-Res, based body weight versus controls. physiologically distinct whose insulin, leptin, gastric inhibitory polypeptide, eotaxin concentrations remained similar had increased macrophage+ crown-like structures white adipose tissue, although macrophage percentages unchanged mice. also decreased splenic CD4+ T cells, elevated GM-CSF, CD11c+ dendritic impaired cell stimulatory capacity (P < 0.05 vs. controls). These parameters unaltered controls. Conclusions Diet-induced results alterations are caused by alone.