Influence of the arterial blood pressure and nonhemodynamic factors on left ventricular hypertrophy in moderate essential hypertension.

摘要: Abstract In a group of 36 untreated patients with mild to moderate essential hypertension (office systolic and diastolic blood pressures (BPs) 160 ± 3.4 102 1.5 mm Hg, respectively), 24-hour ambulatory BP monitoring determination left ventricular (LV) mass index according the formula Devereux were performed. After an overnight fast, samples taken for serum aldosterone, plasma renin activity parathyroid hormone. Urinary catecholamines sampled 24 hours. LV (143.7 8 g/m2) did not correlate significantly either office or BP. The correlation mean (145 3 Hg) was statistically significant: r = 0.395, p 0.026. However, best obtained (90 0.500 (p 0.004). correlated index. (r 0.346, 0.050), aldosterone 0.559, 0.001). There very significant between hormone 0.719, 0.00001) even after adjustment BPs. These results clearly demonstrate that determinants but parameters are well hypertrophy in hypertension. Nonhemodynamic factors important as well. Besides renin-angiotensin-aldosterone system, appears play role cardiac hypertrophy.