Biosafety of Prion Diseases
作者： Henry Baron , Stanley B. Prusiner
DOI: 10.1128/9781555815899.CH26
关键词: Kuru 、 Disease 、 Virology 、 Intensive care medicine 、 Scrapie 、 Biology 、 Blood transfusion 、 Bovine spongiform encephalopathy 、 Transmission (medicine) 、 Chronic wasting disease 、 Biosafety
摘要: Prions are unprecedented transmissible pathogenic agents that cause a group of invariably fatal neurodegenerative diseases, including scrapie (the prototype prion disease in sheep and goats), bovine spongiform encephalopathy (BSE) cattle, chronic wasting (CWD) deer elk, Creutzfeldt-Jakob (CJD) humans. A complete list currently known animal human diseases is provided this chapter. The biosafety issues related to prions have been addressed several guidelines published by health authorities over the years, with recommendations limit potential risk associated contamination laboratory studies as well foods medicinal products. In chapter, authors strive sort out truth from myth legitimate unreasonable relation issues, provide factual basis for concerns an informed rationale actions be implemented. also explore consequences underreaction overconcern respect these issues. transmission blood transfusion or through administration components plasma derivatives has long concern among professionals throughout world. chapter discusses epidemiological data regarding classical CJD blood, deals separately variant (vCJD) its implications safety
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