The shared epitope and severity of rheumatoid arthritis.

摘要: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease that frequently leads to skeletal deformity and disability. A significant genetic contribution the development of RA widely accepted estimated account for approximately 60% risk. 53 To date, strongest association has been reported with human leukocyte antigen (HLA) region and, in particular, HLA-DRB1 alleles share similar amino acid sequence. 37 The recognition this common allele sequence, termed shared epitope (SE), provided insight into genetics clinically diverse disease. Although SE hypothesis was initially proposed explain susceptibility RA, subsequent investigation suggests primary role may be more severe manifestations. Numerous studies have pursued clarification relation; however, there no definite consensus literature. Determination precise relationship between severity profound implications future patient care research. provide prognostic information early course certain subgroups patients or specific outcomes. Clinical trials benefit results by identification randomization according characteristics. Clarification