A Twenty-year Follow-up Study of Seropositive Rheumatoid Arthritis and Seronegative Oligoarthritis

摘要: Rheumatoid factor (RF)-positive rheumatoid arthritis (RA) is a continuously progressive destructive inflammation of joints with systemic features, causing, when not controlled proper treatment, work disability, deterioration life quality, and even premature death. The aim the present study was to ascertain outcome characteristics 103 RF-positive RA patients 64 subjects seronegative oligoarthritis followed prospectively for 20 years. predictive value total 19 demographic, laboratory radiographic entry markers in auguring 20-year 66 poor. Only baseline Larsen score 0100 some degree explained joint destruction (OR 1.4). During years cumulatively 80% at onset disease gave up because RA. disabled had higher mean Health Assessment Questionnaire (HAQ) index scores than retired age or other diseases. There also statistically significant although weak association between HAQ disability 1.13), whereas no independent role remained score. If (0-100) on hands feet 102 erosive did worsen more one point 1-, 3-, 8-, 15and check-ups, nor thereafter, patient considered be permanent remission. Most remissions occurred after 15-year check-up number remission endpoint 27 (26%). progression were often disease-modifying antirheumatic drug (DMARD) and/or prednisolone treatment international agreement criteria severity When 67-100 2-3 three large-joint arthroplasties performed used, incidence severe 29% (30/103) cumulative amyloidosis 14%. In contrast, during 23-year followup generally good: only arthritis. putative diagnoses re-evaluation as follows: psoriatic (PsA) 19, mono/oligo 16, HLA-B27-associated 14, reactive (ReA) 6, osteoarthrosis 4, posttraumatic 2, case each ankylosing spondylitis (AS), lupus erythematosus (SLE). conclusion, mostly expensive community. nonetheless almost impossible predict baseline. Early diagnosis intensive are most prominent challenges. favourable.