Hydroxytyrosyl acetate contributes to the protective effects against oxidative stress of virgin olive oil

摘要: Abstract The effects of virgin olive oil phenols, hydroxytyrosyl acetate (HTy-Ac) and hydroxytyrosol (HTy), on cell integrity steady-state values cellular redox status were assessed in HepG2 cells, as well their potential protective against oxidative stress induced by tert-butyl hydroperoxide ( t -BOOH). Direct treatment for 20 h with 0.5–10 μM HTy or HTy-Ac reduced ROS generation increased glutathione peroxidase activity at the higher concentrations. Furthermore, after -BOOH exposure, pretreatment 2 counteracted viability damage from 1 μM, counterbalanced levels 0.5 μM, protected lipid peroxidation decreased 1 μM antioxidant enzyme activities 1 μM. All these changes statistically significant. presents antioxidative physiological concentrations similar to even slightly than that HTy, thus contributing role oil.