HLA haplotypes with C4B5; evidence for further allelic heterogeneity.
作者： Sandra N. Hing , Carolyn M. Giles , Angela H. L. Fielder , J. Richard Batchelor
DOI: 10.1007/BF00373815
关键词: Immunofixation 、 Biology 、 Phenotype 、 Allele 、 Haplotype 、 Allotype 、 Monoclonal antibody 、 Genetics 、 C4A 、 Molecular biology 、 Allelic heterogeneity
摘要: Twenty-three individuals from various disease groups and normal controls were identified by immunofixation with anti-C4, C4-dependent lysis, determination of Rg (Rodgers) Ch (Chido) phenotypes, immunoblotting C4-specific mouse monoclonal antibody. We found that one haplotype predominates the C4B * 5 allele, HLA-A11, B22(55), Cw3, Bf S, C4A 4B 5, which also carries Ch1,−2, 3 haplotype. The B5 allotype was HLA-1360, HLA-1335 in Caucasoids, HLA-B18 non-Caucasoids; these carried Ch−1, −2, −3 Our results are accord an earlier report two subtypes, B5Rg+ B5Rg− (Roos et al. 1984). specificity antibodies IC4 21312 had been previously related to C4B, respectively, but our suggest they relate more closely determinants.
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