Effect of zinc treatment on intestinal motility in experimentally induced diarrhea in rats.

摘要: Zinc supplementation is a critical new intervention for treating diarrheal episodes in children. Recent studies suggest that administration of zinc along with low osmolarity oral rehydration solutions / salts (ORS) can reduce the duration and severity up to three months. Several mechanisms action has been proposed, however there dearth information about effect on intestinal motility during diarrhea. Male albino Wistar rats (80-100g) were used. The different doses sulphate (25, 50, 100, 150 mg/Kg) number wet faeces was investigated. Intestinal castor oil induced diarrhea assessed using activated charcoal meal effective dose (100mg/Kg) significantly reduced (p< 0.001) (3.0 ± 0.00) compared control (6.8 0.25) This antidiarrheal abolished by propranolol nifedipine. 0.05) transit time (60.7 7.13%) (85.7 2.35%). It concluded reduces frequency output via activation β adrenergic receptor L-type Ca2+ channel.