p115 RhoGEF, a GTPase Activating Protein for G12 and G13
作者： T. Kozasa
DOI: 10.1126/SCIENCE.280.5372.2109
关键词:
摘要: Members of the regulators G protein signaling (RGS) family stimulate intrinsic guanosine triphosphatase (GTPase) activity α subunits certain heterotrimeric guanine nucleotide–binding proteins (G proteins). The nucleotide exchange factor (GEF) for Rho, p115 RhoGEF, has an amino-terminal region with similarity to RGS proteins. Recombinant RhoGEF and a fusion containing amino terminus had specific as GTPase activating toward G12 G13, but not members Gs, Gi, or Gqsubfamilies Gα This GEF may act intermediary in regulation Rho by G13 G12.
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J. R. Hepler, D. M. Berman, A. G. Gilman, T. Kozasa, RGS4 and GAIP are GTPase-activating proteins for Gqα and block activation of phospholipase Cβ by γ-thio-GTP-Gqα Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 428- 432 ,(1997) , 10.1073/PNAS.94.2.428
S. Popov, K. Yu, T. Kozasa, T. M. Wilkie, The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 7216- 7220 ,(1997) , 10.1073/PNAS.94.14.7216
Suki Parks, Eric Wieschaus, The drosophila gastrulation gene concertina encodes a Gα-like protein Cell. ,vol. 64, pp. 447- 458 ,(1991) , 10.1016/0092-8674(91)90652-F
Henrik G. Dohlman, Jeremy Thorner, RGS Proteins and Signaling by Heterotrimeric G Proteins Journal of Biological Chemistry. ,vol. 272, pp. 3871- 3874 ,(1997) , 10.1074/JBC.272.7.3871
Ian P Whitehead, Sharon Campbell, Kent L Rossman, Channing J Der, DBL FAMILY PROTEINS Biochimica et Biophysica Acta. ,vol. 1332, ,(1997) , 10.1016/S0304-419X(96)00040-6
David M Berman, Thomas M Wilkie, Alfred G Gilman, GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits Cell. ,vol. 86, pp. 445- 452 ,(1996) , 10.1016/S0092-8674(00)80117-8
Stefan Offermanns, Valeria Mancino, Jean-Paul Revel, Melvin I Simon, Vascular System Defects and Impaired Cell Chemokinesis as a Result of Gα13 Deficiency Science. ,vol. 275, pp. 533- 536 ,(1997) , 10.1126/SCIENCE.275.5299.533
Matthew J. Hart, Sanju Sharma, Nadia elMasry, Rong-Guo Qiu, Peter McCabe, Paul Polakis, Gideon Bollag, Identification of a Novel Guanine Nucleotide Exchange Factor for the Rho GTPase Journal of Biological Chemistry. ,vol. 271, pp. 25452- 25458 ,(1996) , 10.1074/JBC.271.41.25452
Sreesha P. Srinivasa, Ned Watson, Mark C. Overton, Kendall J. Blumer, Mechanism of RGS4, a GTPase-activating Protein for G Protein α Subunits * Journal of Biological Chemistry. ,vol. 273, pp. 1529- 1533 ,(1998) , 10.1074/JBC.273.3.1529
M. P. Strathmann, M. I. Simon, Gα12 and Gα13 subunits define a fourth class of G protein α subunits Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 5582- 5586 ,(1991) , 10.1073/PNAS.88.13.5582