Loading doses for costly cancer biologicals: sound pharmacology or unnecessary extravagance?
作者： Richard J. Epstein , Bernard M.Y. Cheung
DOI: 10.1016/J.EJCA.2007.12.006
关键词:
摘要: Abstract The rising cost of new molecularly-targeted anticancer drugs has become a major issue in oncology. One small but significant factor contributing to this problem is the routine co-administration loading doses, which may inflate first treatment by as much US$1000. Here, we question cost-effectiveness practice cancer patients on several grounds, including non-urgent pace disease, lack evidence for survival benefit, weak dose-dependency biopharmaceutical efficacy and unproven validity ‘volume distribution’ concept applied target-specific drugs.
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