A dual-targeting strategy for enhanced drug delivery and synergistic therapy based on thermosensitive nanoparticles
作者： Mingxin Wang , Chaoqun You , Zhiguo Gao , Hongshuai Wu , Baiwang Sun
DOI: 10.1080/09205063.2018.1460141
关键词:
摘要: AbstractThe functionalized nanoparticles have been widely studied and reported as carriers of drug transport recently. Furthermore, many groups focused more on developing novel efficient treatment methods, such photodynamic therapy photothermal therapy, since both therapies shown inspiring potential in the application antitumor. The mentioned treatments exhibited superiority cooperative manner showed ability to compensate for adverse effects caused by conventional monotherapy proposed strategies. In view above descriptions, we formulated a thermosensitive delivery system, which achieved enhanced cisplatin two photosensitizers (ICG Ce6) dual-targeting traction. Drawing thin film hydration method, were encapsulated inside nanoparticles. Meanwhile, targeting peptide cRGD molecule folate can be modified surface realize active identification...
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