Chromosomal Imbalances in Papillary Renal Cell Carcinoma : Genetic Differences between Histological Subtypes

摘要: Papillary renal-cell carcinoma (RCC) is a renal variant with distinct gross, microscopic, and cytogenetic features. Recently, type 1 (pale cytoplasm, small-cell) 2 (eosinophilic large-cell) subtype of papillary RCC have been described. Chromosomal alterations associated these tumor types were examined in 25 RCCs by comparative genomic hybridization. Relative copy number gains frequently detected at chromosomes 7p (56%), 7q (44%), 12q (28%), 16q (32%), 17p 17q (76%), 20q (32%). regions that most often lost included 1p (24%), 4q (36%), 6q (40%), 9p 13q Xp Xq Y (73%). There clinical genetic differences between the subtypes RCC. Type tumors higher nuclear grade (P = 0.0012) stage 0.01) had worse prognosis 0.03) than tumors. The DNA per tumor, especially 17p, was significantly < 0.01). These data suggest existence two morphological subgroups Losses chromosome short patient survival Despite small cases, this finding suggests gene on may contribute to progression.