Molecular differential diagnosis of renal cell carcinomas by microsatellite analysis
作者： P Bugert , G Kovacs
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摘要: Recent application of molecular cytogenetic techniques has resulted in a new type genetic classification renal cell tumors. The key aspect the novel diagnostic concept is reflected by biologically distinct entities, each characterized specific combination changes. To work out diagnostic/prognostic approach, we have applied polymorphic microsatellite markers for quick analysis, based on polymerase chain reaction, 82 tumor specimens. We compared results to previously evaluated and histological data. All nonpapillary chromophobe carcinomas, which make up approximately 90% all malignant tumors, subset oncocytomas were correctly diagnosed detection loss heterozygosity at chromosomal sites 1, 2, 3p. Allelic losses regions 8p, 9p, 14q are associated with an advanced pathological stage carcinomas. A chromosomes 6, 10, 13, 17, 21, addition those 1 confirm diagnosis Using this differential tumors could be carried within or 2 days.
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