Deletion of Chromosome 3p14.2-p25 Involving the VHL and FHIT Genes in Conventional Renal Cell Carcinoma
作者： Farkas Sükösd , Tamas Beothe , Naoto Kuroda , Gyula Kovacs , Amrit Pal Kaur
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摘要: Loss of heterozygosity (LOH) at chromosome 3p and inactivation the VHL gene are associated with development conventional renal cell carcinomas (RCCs). Recently, it was suggested that LOH FHIT 3p14.2 is an early event in RCC characteristic for all types RCC. We have analyzed 88 conventional, 30 papillary, 22 chromophobe RCCs regions other loci on 3p. A continuous deletion 3p14.2-p25 harboring genes occurred 96% but only 10% papillary 18% RCCs. Our data indicate specific loss one allele both occurs stage tumorigenesis.
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