Homozygous loss of the interferon genes defines the critical region on 9p that is deleted in lung cancers.
作者： John D. Minna , Adi F. Gazdar , Marion M. Nau , Olufunmilayo I. Olopade , Kathleen Malik
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摘要: Abstract Cytogenetic analyses of non-small cell lung cancer have revealed deletions the short arm chromosome 9 with breakpoints at 9p11-pter in a significant proportion tumors. Recent evidence suggests that homozygous loss interferon (IFN) and methylthioadenosine phosphorylase (MTAP) genes located on 9p tumor suppressor gene closely linked to them is associated acute lymphoblastic leukemia gliomas. We observed alterations DNA sequences which include IFN frequency all types human cancers (20 56 or 36%). The genetic hemizygous as well rearrangement contiguous sequences. In addition these genomic alterations, 10 22 (45%) lines examined lacked MTAP enzyme activity. Overall, 24 (43%) had genes. These findings suggest putative this locus contributes malignant process cancers, other cancer.
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