Nonequivalent lethal equivalents: Models and inbreeding metrics for unbiased estimation of inbreeding load.

摘要: Inbreeding depression, the deterioration in mean trait value progeny of related parents, is a fundamental quantity genetics, evolutionary biology, animal and plant breeding, conservation biology. The magnitude inbreeding depression can be quantified by load, typically measured numbers lethal equivalents, population genetic that allows for comparisons between environments, populations or species. However, there as yet no quantitative assessment which combinations statistical models metrics yield such estimates. Here, we review have been used to estimate load use simulations investigate how unbiased estimates obtained using genomic pedigree-based inbreeding. We simulated binary viability data (i.e., dead versus alive) our example, but concepts apply any exhibits depression. show increasingly popular generalized linear with logit link do not provide comparable measures independent metric used. Runs homozygosity result whereas from pedigrees results slight overestimates. Due widespread some literature cannot compared meaningfully. surveyed reliable wild vertebrate found an average 3.5 haploid equivalents survival sexual maturity. To obtain estimates, encourage researchers logarithmic links maximum-likelihood estimation exponential equation, coefficients calculated runs homozygosity, provided assembled reference genome sufficient quality enough marker are available.