miR-377-dependent BCL-xL regulation drives chemotherapeutic resistance in B-cell lymphoid malignancies
作者： Sayer Al-harbi , Gaurav S. Choudhary , Jey Sabith Ebron , Brian T. Hill , Nagarajavel Vivekanathan
DOI: 10.1186/S12943-015-0460-8
关键词:
摘要: Background BCL-xL is an anti-apoptotic BCL-2 family protein that inhibits apoptosis and overexpressed in many cancers. We have reported acquired resistance to the inhibitor ABT-199 (venetoclax) associated with increased BCL-xL expression. Yet, how mediates chemoresistance hematopoietic malignancies not clear. This finding may help design of new strategies for therapeutic intervention overcome mediated by BCL-xL.
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