Microarray analysis of differential gene expression in temporomandibular joint condylar cartilage after experimentally induced osteoarthritis.
作者： Juanhong Meng , Xuchen Ma , Dalong Ma , Caimin Xu
DOI: 10.1016/J.JOCA.2005.03.010
关键词:
摘要: Summary Objective To identify the gene expression profile of mandibular condylar cartilage after experimentally induced osteoarthritis (OA). Design We studied levels in temporomandibular joint (TMJ) during different stages OA. The pathological characteristics normal, early-stage and late-stage osteoarthritic TMJ were verified by histological techniques. profiles normal measured Affymetrix RAE230A microarrays. Some transcripts confirmed quantitative real-time reverse-transcription PCR analysis. Results A comprehensive, differentially expressed, was obtained progression In total, 138 genes expressed sequence tags up- or down-regulated at least 2-fold. these have been shown to play a role OA, including matrix-degrading proteases, protease inhibitors involved cell growth, apoptosis bone remodeling. However, some that had never reported be related with such as AQP3, SPP2, NOV, DKK3 EGLN3, consistently observed up-regulated this study, suggesting they may OA progression. Conclusion This study provides new Further OA-related provide insights into understanding molecular mechanisms underlying
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