Analysis of gene expression data using self‐organizing maps
作者： Petri Törönen , Mikko Kolehmainen , Garry Wong , Eero Castrén
DOI: 10.1016/S0014-5793(99)00524-4
关键词:
摘要: DNA microarray technologies together with rapidly increasing genomic sequence information is leading to an explosion in available gene expression data. Currently there a great need for efficient methods analyze and visualize these massive data sets. A self-organizing map (SOM) unsupervised neural network learning algorithm which has been successfully used the analysis organization of large files. We have here applied SOM published yeast show that excellent tool visualization profiles.
ensmp.fr
elsevier.com参考文章(10)
Teuvo Kohonen, Self-Organizing Maps ,(1995)
Patrick O. Brown, David Botstein, Exploring the new world of the genome with DNA microarrays Nature Genetics. ,vol. 21, pp. 33- 37 ,(1999) , 10.1038/4462
Teuvo Kohonen, Riitta Hari, Where the abstract feature maps of the brain might come from Trends in Neurosciences. ,vol. 22, pp. 135- 139 ,(1999) , 10.1016/S0166-2236(98)01342-3
Paul T Spellman, Gavin Sherlock, Michael Q Zhang, Vishwanath R Iyer, Kirk Anders, Michael B Eisen, Patrick O Brown, David Botstein, Bruce Futcher, None, Comprehensive Identification of Cell Cycle–regulated Genes of the Yeast Saccharomyces cerevisiae by Microarray Hybridization Molecular Biology of the Cell. ,vol. 9, pp. 3273- 3297 ,(1998) , 10.1091/MBC.9.12.3273
Vishwanath R Iyer, Michael B Eisen, Douglas T Ross, Greg Schuler, Troy Moore, Jeffrey CF Lee, Jeffrey M Trent, Louis M Staudt, James Hudson Jr, Mark S Boguski, Deval Lashkari, Dari Shalon, David Botstein, Patrick O Brown, None, The transcriptional program in the response of human fibroblasts to serum. Science. ,vol. 283, pp. 83- 87 ,(1999) , 10.1126/SCIENCE.283.5398.83
J.W. Sammon, A Nonlinear Mapping for Data Structure Analysis IEEE Transactions on Computers. ,vol. 18, pp. 401- 409 ,(1969) , 10.1109/T-C.1969.222678
P. Tamayo, D. Slonim, J. Mesirov, Q. Zhu, S. Kitareewan, E. Dmitrovsky, E. S. Lander, T. R. Golub, Interpreting patterns of gene expression with self-organizing maps: Methods and application to hematopoietic differentiation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 2907- 2912 ,(1999) , 10.1073/PNAS.96.6.2907
Shelley Chu, Joe DeRisi, Michael Eisen, Jon Mulholland, David Botstein, Patrick O Brown, Ira Herskowitz, The Transcriptional Program of Sporulation in Budding Yeast Science. ,vol. 282, pp. 699- 705 ,(1998) , 10.1126/SCIENCE.282.5389.699
M. B. Eisen, P. T. Spellman, P. O. Brown, D. Botstein, Cluster analysis and display of genome-wide expression patterns Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 14863- 14868 ,(1998) , 10.1073/PNAS.95.25.14863
VR Iyer, JL DeRisi, Patrick O BroWn, Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale Science. ,vol. 278, pp. 680- 686 ,(1997) , 10.1126/SCIENCE.278.5338.680