摘要: Tissue factor (TF) is the high-affinity receptor and cofactor for (F)VII/VIIa. The TF-FVIIa complex primary initiator of blood coagulation plays an essential role in hemostasis. TF expressed on perivascular cells epithelial at organ body surfaces where it forms a hemostatic barrier. also provides additional protection to vital organs, such as brain, lung, heart. Under pathological conditions, can trigger both arterial venous thrombosis. For instance, atherosclerotic plaques contain high levels macrophage foam microvesicles that drives thrombus formation after plaque rupture. In sepsis, inducible expression monocytes leads disseminated intravascular coagulation. cancer patients, tumors release TF-positive into circulation may contribute has nonhemostatic roles. TF-dependent activation cascade generates proteases, FVIIa, FXa, thrombin, which induce signaling variety by cleavage protease-activated receptors. This review will focus roles protective hemostasis
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