Frog Embryo Teratogenesis Assay: Xenopus (FETAX) — A Short-Term Assay Applicable to Complex Environmental Mixtures

摘要: There is no question that a rapid and inexpensive screening tool needed to assess potential teratogenicity. The now classical Ames test (Ames, 1975) other tests screen for mutagenicity carcinogenicity. Although number of relatively bioassays, ranging from the invertebrates through lower vertebrates mammals, as well cell, organ, embryo culture systems, have been used examine teratogenicity, none has adequately validated or widely accepted routine use. tier-testing approach, which uses screens detect hazard indicate need further testing, useful expedient. Comparable tests, however, are not yet applicable teratogenesis testing despite fact there methods available. Among these one we submit may be valid model preliminary assessment teratogens. This model, referred FETAX (Frog Embryo Teratogenesis Assay: Xenopus), applied relative teratogenic risk variety chemicals complex mixtures. mixtures tested come coal-conversion shale-oil technologies their effects compared those similar materials derived natural petroleums.