Acquisition of Responses to a Methamphetamine-Associated Cue in Healthy Humans: Self-Report, Behavioral, and Psychophysiological Measures

摘要: Drug-associated cues elicit conditioned responses in human drug users, and are thought to facilitate a drug-seeking behavior. Yet, little is known about how these associations acquired, or the specificity of response modalities. In this study, healthy, nondependent volunteers (N=90) completed conditioning paradigm which they received moderate dose methamphetamine paired with one stimulus placebo another stimulus, each on two separate occasions. Their were measured behavioral preference, self-reported 'liking', emotional reactivity, attentional bias measures, both before after conditioning. Following procedure, subjects exhibited positive toward methamphetamine-associated cue, compared stimulus. addition, who reported greater subjective effects during displayed more robust This work demonstrates that healthy readily acquire neutral stimuli drug. The procedure has significant value study individual variation acquisition as possible risk factor for taking, neural basis responses.