Neuroprotective effects of the Buyang Huanwu decoction on functional recovery in rats following spinal cord injury.
作者： Dong Xian-Hui , He Xiao-Ping , Gao Wei-Juan
DOI: 10.1179/2045772314Y.0000000273
关键词:
摘要: Background The Buyang Huanwu decoction (BYHWD) is a traditional Chinese herbal prescription and has been used in China to treat spinal cord injury (SCI) for hundreds of years. Clinical trials have shown that BYHWD improves the outcome SCI clinical trials, but mechanisms are not known. This study observed neuroprotective effects on nerve cells after investigated possible mechanisms. Materials methods Forty female Wistar rats were randomized equally four groups treated by sham injury, SCI, BYHWD, or methylprednisolone (MP). Basso, Beattie, Bresnahan (BBB) score was evaluate hind-limb locomotor function. Neuron apoptosis assessed terminal deoxynucleotidyl transferase dUTP nick end labeling staining caspase-3, Bax, Bcl-2 mRNA protein expression evaluated real-time quantitative polymerase chain reaction Western blotting, respectively. Results In group, walking mildly abnormal anesthesia recovered ...
maneyonline.com参考文章(31)
Samuel David, Juan Guillermo Zarruk, Nader Ghasemlou, Inflammatory pathways in spinal cord injury. International Review of Neurobiology. ,vol. 106, pp. 127- 152 ,(2012) , 10.1016/B978-0-12-407178-0.00006-5
Gracee Agrawal, Candace Kerr, Nitish V. Thakor, Angelo H. All, Characterization of graded multicenter animal spinal cord injury study contusion spinal cord injury using somatosensory-evoked potentials. Spine. ,vol. 35, pp. 1122- 1127 ,(2010) , 10.1097/BRS.0B013E3181BE5FA7
Samuel David, Rubèn López-Vales, V. Wee Yong, Harmful and beneficial effects of inflammation after spinal cord injury Handbook of Clinical Neurology. ,vol. 109, pp. 485- 502 ,(2012) , 10.1016/B978-0-444-52137-8.00030-9
Richard J. Youle, Andreas Strasser, The BCL-2 protein family: opposing activities that mediate cell death Nature Reviews Molecular Cell Biology. ,vol. 9, pp. 47- 59 ,(2008) , 10.1038/NRM2308
R.M. Evans, M. Davies, ScoreCentre: A computer program to assist with collection and calculation of BBB locomotor scale data Journal of Neuroscience Methods. ,vol. 194, pp. 102- 107 ,(2010) , 10.1016/J.JNEUMETH.2010.09.018
Lian-Dong Zhao, Jian-Hua Wang, Guang-Rong Jin, Ying Zhao, Hai-Jun Zhang, Neuroprotective effect of Buyang Huanwu decoction against focal cerebral ischemia/reperfusion injury in rats--time window and mechanism. Journal of Ethnopharmacology. ,vol. 140, pp. 339- 344 ,(2012) , 10.1016/J.JEP.2012.01.026
Joshua T. Johnstone, Paul D. Morton, Arumugam R. Jayakumar, Andrea L. Johnstone, Han Gao, Valerie Bracchi-Ricard, Damien D. Pearse, Michael D. Norenberg, John R. Bethea, Inhibition of NADPH Oxidase Activation in Oligodendrocytes Reduces Cytotoxicity Following Trauma PLoS ONE. ,vol. 8, pp. e80975- ,(2013) , 10.1371/JOURNAL.PONE.0080975
D. Ryan Ormond, Craig Shannon, Julius Oppenheim, Richard Zeman, Kaushik Das, Raj Murali, Meena Jhanwar-Uniyal, Stem Cell Therapy and Curcumin Synergistically Enhance Recovery from Spinal Cord Injury PLoS ONE. ,vol. 9, pp. e88916- ,(2014) , 10.1371/JOURNAL.PONE.0088916
Aldric T. Hama, Peter Germano, Matthew S. Varghese, Benjamin F. Cravatt, G. Todd Milne, James P. Pearson, Jacqueline Sagen, Fatty Acid Amide Hydrolase (FAAH) Inhibitors Exert Pharmacological Effects, but Lack Antinociceptive Efficacy in Rats with Neuropathic Spinal Cord Injury Pain PLoS ONE. ,vol. 9, pp. e96396- ,(2014) , 10.1371/JOURNAL.PONE.0096396
Guangxian Cai, Baiyan Liu, Wei Liu, Xianhui Tan, Jianhui Rong, Xuemei Chen, Li Tong, Jiangang Shen, Buyang Huanwu Decoction can improve recovery of neurological function, reduce infarction volume, stimulate neural proliferation and modulate VEGF and Flk1 expressions in transient focal cerebral ischaemic rat brains Journal of Ethnopharmacology. ,vol. 113, pp. 292- 299 ,(2007) , 10.1016/J.JEP.2007.06.007