Elevated Estrogen Receptor Expression in Human Prostatic Stromal Cells by Androgen Ablation Therapy
作者： Inge G. Kruithof-Dekker , Bernard Tetu , Patrick J.A. Janssen , Theodorus H. Van Der Kwast
DOI: 10.1016/S0022-5347(01)65749-5
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摘要: AbstractPurpose: The presence of estrogen receptors (ER) in human prostatic tissue is a longstanding, controversial issue. In few experimental animal models androgen deprivation was shown to be associated with spontaneous increased ER expression tissue. We intended study whether these observations also apply tissue.Materials and Methods: Estrogen receptor by stromal glandular cells studied immunohistochemistry prostatectomy specimens 21 patients prostate cancer, treated for 3 months luteinizing hormone-releasing hormone (LHRH) agonist flutamide. addition 2 estrogens were examined. For comparison, series 18 untreated patients.Results: blockade showed atrophic changes the gland as well basal cell hyperplasia, features characteristic this therapy. Although pr...
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