Effects of pentoxifylline on coagulation profile and disseminated intravascular coagulation incidence in Egyptian septic neonates.

摘要: Summary Background and objectives:  Neonatal sepsis is frequently associated with pathological activation of the coagulation system, leading to microcirculatory derangement multiple organ dysfunction syndrome (MODS). The key role in pathogenesis has been attributed proinflammatory cytokines. These trigger development disseminated intravascular (DIC) via tissue factor-dependent pathway coagulation. Pentoxifylline (PTX), a methylxanthine derivative that used peripheral vascular disease, potential modify inflammatory response. current work was designed evaluate protective effects PTX against sepsis-induced Egyptian neonates. Methods:  A double-blind placebo-controlled quasi-randomized design used. Thirty-seven neonates were randomly allocated into two groups. Seventeen patients given (5 mg/kg/h for 6 h; 6 successive days). Twenty received equivalent volume normal saline represented placebo group. Prothrombin time (PT), Activated partial thromboplastin (APTT), fibrinogen, d-dimer, C-reactive protein (CRP), complete blood count (CBC), also hemodynamic parameters comprising arterial pressure, heart rate, capillary refill urinary output assessed both groups before after treatment. Results:  Coagulation showed no significant differences. However, higher incidence DIC observed group neonates. significantly lowered percentage bleeding (P = 0·0128) less frequent use FFP (35·53% vs. 80% group, P = 0·003). Incidence MODS lower (P = 0·037) hospital stay duration survivors shorter (P = 0·044) treated-infants. Conclusion:  protects It shortened length stay.